This paper illustrates how biological and clinical problems stimulate research in biomedical informatics and how such research contributes to their solution. The computational models described use techniques from Logic Programming, Machine Learning, Computer Vision, and Biomathematics. They address problems in the development, growth, and repair of oral and craniofacial tissues arising in cell biology, clinical genetics, and dentistry. At the micro-level, the dynamic interaction of cells in the oral epithelium is modeled. At the macro-level, models are constructed of either the craniofacial shape of an individual or the craniofacial shape differences within and between healthy and congenitally abnormal populations. In between, in terms of scale, there are models of normal dentition and the use of computerized expert knowledge to guide the design of dental prostheses used to restore function in partially edentulous patients.

Original publication




Journal article


Adv Dent Res

Publication Date





61 - 64


Adult, Cephalometry, Child, Computer Simulation, Computer-Aided Design, Dental Prosthesis Design, Dentition, Denture, Partial, Removable, Epithelial Cells, Face, Female, Humans, Imaging, Three-Dimensional, Jaw, Jaw, Edentulous, Partially, Male, Maxillofacial Development, Medical Informatics Computing, Models, Biological, Mouth Mucosa