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We propose an individual cell based model for epithelial cell interactions. The model includes biological processes such as cell division, differentiation, adhesion, and death. Cell types include stem, transit amplifying, intermediate, mature, and dead. Stem and transit amplifying cells are allowed to divide provided they are on the basement membrane. In particular, the roles of differential adhesion and cell division during the development are discussed. The typical ordered structure of a healthy epithelium is shown to arise provided differential adhesion and cell division are modeled appropriately.

Original publication

DOI

10.1109/tnb.2007.891907

Type

Journal article

Journal

Ieee transactions on nanobioscience

Publication Date

03/2007

Volume

6

Pages

77 - 85

Addresses

Eastman Dental Institute, University College London (UCL), London WC1X 8LD, UK. satheesh@doc.ic.ac.uk

Keywords

Epithelial Cells, Animals, Humans, Cell Adhesion, Cell Communication, Cell Proliferation, Cell Aggregation, Cell Size, Models, Biological, Computer Simulation