Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Linkage disequilibrium across the human genome is generally lower in West Africans than Europeans. However in the 5q31 region, which is rich in immune genes, we find significantly more examples of apparent nonrecombination between distant marker pairs in West Africans. Much of this effect is due to SNPs that are absent in Europeans, possibly reflecting recent positive selection in the West African population.

Original publication




Journal article


Genes and immunity

Publication Date





723 - 727


University Department of Paediatrics, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, Oxon OX3 7BN, UK.


Chromosomes, Human, Pair 5, Humans, Genetic Markers, Pedigree, Genetics, Population, Haplotypes, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Genome, Human, African Continental Ancestry Group, European Continental Ancestry Group