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Linkage disequilibrium across the human genome is generally lower in West Africans than Europeans. However in the 5q31 region, which is rich in immune genes, we find significantly more examples of apparent nonrecombination between distant marker pairs in West Africans. Much of this effect is due to SNPs that are absent in Europeans, possibly reflecting recent positive selection in the West African population.

Original publication

DOI

10.1038/sj.gene.6364250

Type

Journal article

Journal

Genes and immunity

Publication Date

12/2005

Volume

6

Pages

723 - 727

Addresses

University Department of Paediatrics, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, Oxon OX3 7BN, UK.

Keywords

Chromosomes, Human, Pair 5, Humans, Genetic Markers, Pedigree, Genetics, Population, Haplotypes, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Genome, Human, African Continental Ancestry Group, European Continental Ancestry Group