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Young women with neurofibromatosis type 1 (NF1) are reported to have a higher risk of breast cancer than others, and this might have implications for screening programmes. Our aim was to calculate this risk.An all-England linked data set of hospital admissions and deaths was analysed to determine age-specific rates of breast cancer in women with NF1 and controls.The age-specific excess risk of breast cancer, comparing the NF1 cohort with the control cohort, was elevated 6.5-fold (95% confidence interval 2.6-13.5) in women aged 30-39 years. There was a 4.4 (2.5-7.0) times higher risk among women aged 40-49.Women with NF1 develop breast cancer at younger ages than the general population.

Original publication




Journal article


British journal of cancer

Publication Date





1546 - 1548


Unit of Health-Care Epidemiology, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.


Humans, Neurofibromatosis 1, Breast Neoplasms, Prognosis, Risk Factors, Case-Control Studies, Follow-Up Studies, Age Factors, Adult, Aged, Aged, 80 and over, Middle Aged, England, Female