Assessing the pandemic risk posed by specific non-human influenza A viruses is an important goal in public health research. As influenza virus genome sequencing becomes cheaper, faster, and more readily available, the ability to predict pandemic potential from sequence data could transform pandemic influenza risk assessment capabilities. However, the complexities of the relationships between virus genotype and phenotype make such predictions extremely difficult. The integration of experimental work, computational tool development, and analysis of evolutionary pathways, together with refinements to influenza surveillance, has the potential to transform our ability to assess the risks posed to humans by non-human influenza viruses and lead to improved pandemic preparedness and response.

Original publication

DOI

10.7554/eLife.03883

Type

Journal article

Journal

eLife

Publication Date

16/10/2014

Volume

3

Addresses

Colin A Russell Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

Keywords

Humans, Influenza A virus, Risk Assessment, Public Health, Base Sequence, Geography, Models, Biological, Influenza, Human, Biological Evolution, Pandemics, Epidemiological Monitoring