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An open paired randomised comparison of intramuscular chloroquine (3.5 mg base/kg every 6 h) and intramuscular quinine (20 mg salt/kg followed by 10 mg/kg every 12 h) was carried out in 50 Gambian children with severe falciparum malaria. 8 children died, 6 from the quinine-treated and 2 from the chloroquine-treated group. Chloroquine reduced parasitaemia significantly more rapidly than did quinine, but other measures of the therapeutic response were similar in the two groups. Quinine injections were painful. These findings do not support the proposition that quinine is intrinsically superior to chloroquine in the treatment of severe drug-sensitive falciparum malaria.

Original publication

DOI

10.1016/s0140-6736(89)91918-1

Type

Journal article

Journal

Lancet (london, england)

Publication Date

12/1989

Volume

2

Pages

1313 - 1316

Addresses

Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Thailand.

Keywords

Animals, Humans, Plasmodium falciparum, Malaria, Quinine, Chloroquine, Administration, Oral, Injections, Intramuscular, Random Allocation, Child, Child, Preschool, Infant, Gambia, Female, Male