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In the Lao PDR (Laos), urban dengue is an increasingly recognised public health problem. We describe a dengue-1 virus outbreak in a rural northwestern Lao forest village during the cool season of 2008. The isolated strain was genotypically "endemic" and not "sylvatic," belonging to the genotype 1, Asia 3 clade. Phylogenetic analyses of 37 other dengue-1 sequences from diverse areas of Laos between 2007 and 2010 showed that the geographic distribution of some strains remained focal overtime while others were dispersed throughout the country. Evidence that dengue viruses have broad circulation in the region, crossing country borders, was also obtained. Whether the outbreak arose from dengue importation from an urban centre into a dengue-naïve community or crossed into the village from a forest cycle is unknown. More epidemiological and entomological investigations are required to understand dengue epidemiology and the importance of rural and forest dengue dynamics in Laos.

Original publication

DOI

10.1371/journal.pntd.0002360

Type

Journal article

Journal

Plos neglected tropical diseases

Publication Date

01/2013

Volume

7

Addresses

UMR_D 190 Emergence des Pathologies Virales, Aix-Marseille Université, IRD French Institute of Research for Development, EHESP French School of Public Health, Marseille, France. audrey@tropmedres.ac

Keywords

Humans, Dengue Virus, Dengue, RNA, Viral, Cluster Analysis, Sequence Analysis, DNA, Disease Outbreaks, Phylogeny, Genotype, Molecular Sequence Data, Adolescent, Adult, Child, Child, Preschool, Rural Population, Laos, Female, Male, Young Adult