Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Hyperreactive malarial splenomegaly (HMS), a common cause of massive splenomegaly in malaria-endemic regions, is defined as persistent splenomegaly without demonstrable underlying disease. Previous studies have found HMS more frequently in certain tribes in Papua New Guinea, Uganda and Nigeria, with strong familial associations in Uganda and Papua New Guinea. This case-control study aimed to determine the extent of familial association of splenomegaly and the pattern of segregation of the condition in families in Ghana. It involved 22 HMS cases with 99 relatives, and 15 population controls of similar socio-economic background with 51 relatives. The pedigree of each family was recorded. Clinical and laboratory data were collected on all participants, including the presence and degree of splenomegaly. Relatives with splenomegaly were identified for 27% of HMS cases and for 6.7% of population controls (P=0.04). There were significant differences in the IgM levels, which were higher (P=0.005), and the haemoglobin levels, which were lower (P=0.009), in cases compared with controls. In Ghana, relatives of HMS cases are more likely to have splenomegaly than population controls, but with no obvious pattern of Mendelian segregation. HMS aetiology in Ghana is likely to be complex, involving multiple genetic and environmental factors.

Original publication

DOI

10.1016/j.trstmh.2005.07.006

Type

Journal article

Journal

Transactions of the royal society of tropical medicine and hygiene

Publication Date

01/2006

Volume

100

Pages

68 - 73

Addresses

Department of Medicine, Komfo Anokye Teaching Hospital, P.O. Box 1934, Kumasi, Ghana. rmpeprah@liverpool.ac.uk

Keywords

Humans, Malaria, Falciparum, Splenomegaly, Case-Control Studies, Pedigree, Adult, Aged, Middle Aged, Ghana, Female, Male