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The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A --> G) in 33 isolates, all from Thailand. Mutations of Pvdhps and Pvdhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.

Original publication

DOI

10.1128/aac.49.10.4393-4395.2005

Type

Journal article

Journal

Antimicrobial agents and chemotherapy

Publication Date

10/2005

Volume

49

Pages

4393 - 4395

Addresses

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Keywords

Animals, Plasmodium vivax, Malaria, Vivax, Sulfadoxine, Pyrimethamine, Dihydropteroate Synthase, DNA, Protozoan, Codon, Drug Combinations, Antimalarials, Prevalence, Nucleic Acid Amplification Techniques, Polymerase Chain Reaction, Protein Structure, Tertiary, Drug Resistance, Haplotypes, Point Mutation, Polymorphism, Genetic, Genes, Protozoan, Thailand