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The evolution of sickle cell disease illustrates the powerful selective pressure of malaria in Africa, and candidate gene association studies have identified more than ten putative susceptibility determinants involving erythrocytes or the immune system. Efforts at present are aimed at understanding the functional basis of known associations, and at developing both linkage- and association-based approaches of genome-wide screening for novel susceptibility factors.

Original publication

DOI

10.1016/s0959-437x(00)00087-3

Type

Journal article

Journal

Current opinion in genetics & development

Publication Date

06/2000

Volume

10

Pages

320 - 324

Addresses

Wellcome Trust Centre for Human Genetics, Oxford, OX2 7BN, UK. dominic.kwiatkowski@paediatrics.ox.ac.uk

Keywords

Humans, Malaria, Anemia, Sickle Cell, Genetic Predisposition to Disease, African Continental Ancestry Group, Africa, Immunity, Innate