Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The S-S reducing agent, dithiothreitol (DTT) altered the properties of nicotinic receptors in rat superior cervical ganglia such that (i) carbachol became less active as a depolarizing agent and (ii) bromo- acetylcholine produced an irreversible depolarization. The latter was temporarily annulled by hexamethonium (which retained antagonist properties), but returned when hexamethonium was removed. It is concluded that ganglionic nicotinic receptors might be quite similar to those for monoquaternary agonists in leech dorsal muscle.

Type

Other

Publication Date

1976

Volume

56

Pages

128 - 130