Many genes have been shown to be involved in host susceptibility to the severe forms of Plasmodium falciparum malaria but it is likely that a large number of malaria-susceptibility genes remain to be determined. We conducted a large case-control study of children with the severe forms of this disease-cerebral malaria and severe malarial anaemia--to attempt to identify these genes. Over 1200 children in The Gambia were typed for polymorphisms of the intercellular adhesion molecule 1 (ICAM-1), complement receptor 1 (CR-1) and interleukin 1 receptor antagonist (IL-IRA) genes. None of the polymorphisms typed was significantly associated with severe disease. These data differed significantly from the results of a previous study (Chi 2 = 8.81; P = 0.003) in which the ICAM-1 gene polymorphism was shown to be significantly associated with cerebral malaria in a case-control study of 547 subjects in Kenya. This suggests that there may be heterogeneity in genetic susceptibility to this condition between these 2 African populations.

Original publication

DOI

10.1016/s0035-9203(98)91026-4

Type

Journal article

Journal

Transactions of the Royal Society of Tropical Medicine and Hygiene

Publication Date

05/1998

Volume

92

Pages

312 - 316

Addresses

Wellcome Trust Centre for Human Genetics, Oxford, UK. richard@well.ox.ac.uk

Keywords

Humans, Malaria, Falciparum, Genetic Predisposition to Disease, Intercellular Adhesion Molecule-1, Receptors, Complement, Receptors, Interleukin-1, Genetic Screening, Case-Control Studies, Polymerase Chain Reaction, Genotype, Child, Child, Preschool, Infant, Gambia