Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Many genes have been shown to be involved in host susceptibility to the severe forms of Plasmodium falciparum malaria but it is likely that a large number of malaria-susceptibility genes remain to be determined. We conducted a large case-control study of children with the severe forms of this disease-cerebral malaria and severe malarial anaemia--to attempt to identify these genes. Over 1200 children in The Gambia were typed for polymorphisms of the intercellular adhesion molecule 1 (ICAM-1), complement receptor 1 (CR-1) and interleukin 1 receptor antagonist (IL-IRA) genes. None of the polymorphisms typed was significantly associated with severe disease. These data differed significantly from the results of a previous study (Chi 2 = 8.81; P = 0.003) in which the ICAM-1 gene polymorphism was shown to be significantly associated with cerebral malaria in a case-control study of 547 subjects in Kenya. This suggests that there may be heterogeneity in genetic susceptibility to this condition between these 2 African populations.

Original publication

DOI

10.1016/s0035-9203(98)91026-4

Type

Journal article

Journal

Transactions of the Royal Society of Tropical Medicine and Hygiene

Publication Date

05/1998

Volume

92

Pages

312 - 316

Addresses

Wellcome Trust Centre for Human Genetics, Oxford, UK. richard@well.ox.ac.uk

Keywords

Humans, Malaria, Falciparum, Genetic Predisposition to Disease, Intercellular Adhesion Molecule-1, Receptors, Complement, Receptors, Interleukin-1, Genetic Screening, Case-Control Studies, Polymerase Chain Reaction, Genotype, Child, Child, Preschool, Infant, Gambia