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Intercellular adhesion molecule 1 (ICAM-1) mediates the binding of Plasmodium falciparum to vascular endothelium. In a case-control study of falciparum malaria in Gambian children, we have looked for evidence that a generalized increase in expression of ICAM-1 is associated with cerebral malaria. Plasma levels of circulating ICAM-1 (cICAM-1) were significantly higher in 246 children with acute malaria than in 156 children with non-malarial illnesses. cICAM-1 levels correlated with levels of tumour necrosis factor (TNF), interleukin 1 alpha (IL-1 alpha) and interferon gamma, supporting the view that these cytokines are responsible for a general upregulation of ICAM-1 expression in malaria. However, while it has been previously shown that TNF and IL-1 alpha levels were related to disease severity, this was not the case for cICAM-1. It may be that differences in the distribution of ICAM-1, rather than its total level of expression, are critical in determining the clinical outcome in malaria.

Original publication

DOI

10.1016/s0035-9203(96)90244-8

Type

Journal article

Journal

Transactions of the royal society of tropical medicine and hygiene

Publication Date

05/1996

Volume

90

Pages

274 - 276

Addresses

Department of Paediatrics, John Radcliffe Hospital, Oxford, UK.

Keywords

Humans, Malaria, Cerebral, Coma, Tumor Necrosis Factor-alpha, Intercellular Adhesion Molecule-1, Interleukin-1, Severity of Illness Index, Regression Analysis, Case-Control Studies, Child, Child, Preschool, Infant, Interferon-gamma