Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.

Original publication

DOI

10.1038/ng.2385

Type

Journal article

Journal

Nature genetics

Publication Date

09/2012

Volume

44

Pages

991 - 1005

Addresses

Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

Keywords

DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Animals, Humans, Mice, Insulin, Blood Glucose, Fasting, Gene Frequency, Quantitative Trait Loci, Osmolar Concentration, Adult, Female, Male, Metabolic Networks and Pathways, Genome-Wide Association Study