Haplotype-based techniques are being used to estimate the relative age of alleles--particularly in screening loci for signals of recent positive selection--but does this approach capture even coarse age differences? Using simulations and empirical data from the International HapMap Project, we show that a simple pairwise metric of haplotype homozygosity gives significantly higher mean values for human single-nucleotide-polymorphism alleles that appear to be derived than for those that appear to be ancestral, as determined by comparison with the chimpanzee genome. Our results support the use of haplotype-based techniques, such as extended haplotypic homozygosity, to assess the age of alleles.

Original publication

DOI

10.1086/504160

Type

Journal article

Journal

American journal of human genetics

Publication Date

06/2006

Volume

78

Pages

1053 - 1059

Addresses

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom. afry@well.ox.ac.uk

Keywords

Humans, Age Factors, Haplotypes, Homozygote, Alleles, Genome, Human