Malaria is a global problem, and there is a critical need for further understanding of the disease process. When malarial parasites invade and develop within the bloodstream, they stimulate a profound host response whose main clinical sign is fever. To explore this response, we measured host gene expression in whole blood from Kenyan children hospitalized with either acute malaria or other febrile illnesses. Genomewide analysis of expression identified 2 principal gene-expression profiles related to neutrophil and erythroid activity. In addition to these general acute responses, a third gene-expression profile was associated with host parasitemia; mediators of erythrophagocytosis and cellular stress were notable components of this response. The delineation of subjects on the basis of patterns of gene expression provides a molecular perspective of the host response to malaria and further functional insight into the underlying processes of pathogenesis.

Original publication

DOI

10.1086/429297

Type

Journal article

Journal

The Journal of infectious diseases

Publication Date

05/2005

Volume

191

Pages

1599 - 1611

Addresses

Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK. griffmj@stanford.edu

Keywords

Erythrocytes, Neutrophils, Humans, Parasitemia, Malaria, Leukocyte Count, Gene Expression Profiling, Gene Expression, Phenotype, Child, Child, Preschool, Infant, Kenya, Female, Male