Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The Sahel that extends from the Atlantic Ocean to the Ethiopian highland is a historical reservoir of Africa's cultures and grandest populations and a known arena of ancient and recent migrations. We are interested in the issue whether such migrations were also carriers of genetic traits and whether this introgression could be associated with population genetic markers. Based on analysis of Y-chromosome haplogroups, we present evidence that the sickle gene, one of the major protective polymorphisms known in malaria, has in fact found its way only recently to the gene pool of the populations in eastern Sahel. We discuss the possible dynamics of the process and give estimates of the age of the introduction of the S allele into eastern Sahel.

Original publication

DOI

10.1038/sj.ejhg.5201892

Type

Journal article

Journal

European journal of human genetics : EJHG

Publication Date

11/2007

Volume

15

Pages

1183 - 1185

Addresses

Institute of Endemic Diseases, Medical Campus, University of Khartoum, Khartoum, Sudan.

Keywords

Chromosomes, Human, Y, Humans, Anemia, Sickle Cell, Hemoglobin, Sickle, Case-Control Studies, Emigration and Immigration, Gene Frequency, Haplotypes, Africa, Northern, Male