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Molecular HLA class II typing of greater than 1700 individuals from The Gambia in West Africa and Malawi in South-Central Africa revealed a striking diversity of HLA DRB-DQB haplotypes as defined by restriction fragment length polymorphism (RFLP); this diversity is twice as extensive as that found in northern Europeans. Despite this diversity, sequence and PCR/oligonucleotide analysis showed that the recently described variant DRB1*1304 is the commonest DRB1 allele in The Gambia. The sequence, geographical distribution, and RFLP association of this allele, together with homozygosity test results, suggest that DRB1*1304 may have arisen from DRB1*1102 and have reached its remarkably high frequency as a result of recent directional selection. The prevalence of this unusual allele has implications for trials of subunit vaccines in this area. The extensive and distinctive HLA class II region polymorphism in sub-Saharan Africans is consistent with evidence from other genetic loci implying an African origin of modern Homo sapiens.

Original publication

DOI

10.1073/pnas.89.6.2277

Type

Journal article

Journal

Proceedings of the national academy of sciences of the united states of america

Publication Date

03/1992

Volume

89

Pages

2277 - 2281

Addresses

Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom.

Keywords

Leukocytes, Humans, DNA, Histocompatibility Antigens Class II, HLA-DR Antigens, Restriction Mapping, Genes, MHC Class II, Gene Frequency, Haplotypes, Homozygote, Polymorphism, Restriction Fragment Length, Alleles, African Continental Ancestry Group, Gambia, Genetic Variation, HLA-DRB1 Chains