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Allelic frequencies of a (CCTTT)(n) pentanucleotide repeat in the NOS2A promoter region were determined in a total of 1393 unrelated individuals from five specific population groups in four continents: Africa, Europe, Asia, and the Caribbean. There were highly significant differences in allele frequencies between the ethnically diverse populations. The repeat variation may have implications for the selective pressure of malaria or other infectious diseases that may operate at the NOS2 locus.

Original publication

DOI

10.1006/niox.2000.0290

Type

Journal article

Journal

Nitric oxide : biology and chemistry

Publication Date

08/2000

Volume

4

Pages

379 - 383

Addresses

Wolfson Institute for Biomedical Research, University College London, Cruciform Building, London, WC1E 6AU, United Kingdom. w.xu@ucl.ac.uk

Keywords

Humans, Infection, Genetic Predisposition to Disease, DNA, Microsatellite Repeats, Gene Frequency, Polymorphism, Genetic, Continental Population Groups, Nitric Oxide Synthase, Nitric Oxide Synthase Type II, Promoter Regions, Genetic