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To investigate a putative link between genetically determined variations in Toll-like receptor 2 (TLR2) and the occurrence of severe Staphylococcus aureus infection, the functional Arg753Gln single-nucleotide polymorphism and the GT repeat microsatellite in the TLR2 gene were examined in a large case-control study. No associations with disease or mortality attributable to these features were found.

Original publication




Journal article


Clinical and diagnostic laboratory immunology

Publication Date





1194 - 1197


Nuffield Department of Clinical Medicine, University of Oxford, Level 4, John Radcliffe Hospital, Oxford, OX3 9DU United Kingdom.


Humans, Staphylococcus aureus, Staphylococcal Infections, Genetic Predisposition to Disease, Membrane Glycoproteins, Receptors, Cell Surface, Case-Control Studies, Polymorphism, Single Nucleotide, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Child, Preschool, Infant, Infant, Newborn, Female, Male, Toll-Like Receptors, Toll-Like Receptor 2