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To investigate a putative link between genetically determined variations in Toll-like receptor 2 (TLR2) and the occurrence of severe Staphylococcus aureus infection, the functional Arg753Gln single-nucleotide polymorphism and the GT repeat microsatellite in the TLR2 gene were examined in a large case-control study. No associations with disease or mortality attributable to these features were found.

Original publication

DOI

10.1128/cdli.11.6.1194-1197.2004

Type

Journal article

Journal

Clinical and diagnostic laboratory immunology

Publication Date

11/2004

Volume

11

Pages

1194 - 1197

Addresses

Nuffield Department of Clinical Medicine, University of Oxford, Level 4, John Radcliffe Hospital, Oxford, OX3 9DU United Kingdom. catrin.moore@paediatrics.ox.ac.uk

Keywords

Humans, Staphylococcus aureus, Staphylococcal Infections, Genetic Predisposition to Disease, Membrane Glycoproteins, Receptors, Cell Surface, Case-Control Studies, Polymorphism, Single Nucleotide, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Child, Preschool, Infant, Infant, Newborn, Female, Male, Toll-Like Receptors, Toll-Like Receptor 2