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Variable major lipoprotein (Vmp) is a major tumor necrosis factor (TNF)-inducing component of Borrelia recurrentis, the agent of louse-borne relapsing fever. B. recurrentis Vmp rapidly stimulates nuclear translocation of NF-kappaB and proinflammatory cytokine gene expression in the human monocyte-like cell line MonoMac 6. By overexpressing disabled mutant IkappaBalpha in MonoMac 6 cells cotransfected with a reporter gene, we provide evidence that NF-kappaB is essential for the transcriptional activation of TNF in this system.

Original publication

DOI

10.1128/iai.68.9.5447-5449.2000

Type

Journal article

Journal

Infection and immunity

Publication Date

09/2000

Volume

68

Pages

5447 - 5449

Addresses

Molecular Infectious Disease Group, Institute of Molecular Medicine, The John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom. iudalova@molbiol.ox.ac.uk

Keywords

Cell Line, Humans, Borrelia, Tumor Necrosis Factor-alpha, Bacterial Proteins, NF-kappa B, RNA, Messenger, Cytokines, Transcriptional Activation