Hepatitis C virus (HCV) is a blood-borne pathogen that poses a significant threat to public health worldwide. The genetic diversity and distribution of HCV genotypes in non-Western countries, particularly subSaharan Africa, is poorly documented. This study reports a phylogenetic analysis of core and NS5B gene sequences of 37 HCV strains sampled in Cameroon. A high level of genetic diversity of both genotypes 1 and 4 was found, indicating a unique pattern of long-term HCV infection that has not been observed elsewhere. These results lead to the hypothesis that these HCV genotypes originated and diversified in west Central Africa before spreading to other regions.

Original publication

DOI

10.1099/vir.0.19240-0

Type

Journal article

Journal

The Journal of general virology

Publication Date

09/2003

Volume

84

Pages

2333 - 2341

Addresses

Institute of Medical Microbiology and Immunology, University of Bonn, Sigmund-Freud Strasse 25, 53105 Bonn, Germany. ndjomou_j@hotmail.com

Keywords

Humans, Hepacivirus, Hepatitis C, Viral Nonstructural Proteins, Viral Core Proteins, RNA, Viral, Endemic Diseases, Phylogeny, Molecular Sequence Data, Adult, Aged, Aged, 80 and over, Middle Aged, Cameroon, Female, Male, Genetic Variation, Molecular Epidemiology