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Several human genetic disorders of hemoglobin have risen in frequency because of the protection they offer against death from malaria, sickle-cell anemia being a canonical example. Here we address the issue of why this highly protective mutant, present at high frequencies in subSaharan Africa, is uncommon in Mediterranean populations that instead harbor a diverse range of thalassemic hemoglobin disorders. We demonstrate that these contrasting profiles of malaria-protective alleles can arise and be stably maintained by two well-documented phenomena: an alleviation of the clinical severity of alpha- and beta-thalassemia in compound thalassemic genotypes and a cancellation of malaria protection when alpha-thalassemia and the sickle-cell trait are coinherited. The complex distribution of globin mutants across Africa and the Mediterranean can therefore be explained by their specific intracellular interactions.

Original publication

DOI

10.1073/pnas.0910840106

Type

Journal article

Journal

Proceedings of the National Academy of Sciences of the United States of America

Publication Date

12/2009

Volume

106

Pages

21242 - 21246

Addresses

Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom.

Keywords

Humans, Malaria, Anemia, Sickle Cell, Thalassemia, Hemoglobins, Abnormal, Epistasis, Genetic, Gene Frequency, Africa, Mediterranean Islands