We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region.

Original publication

DOI

10.1016/j.virol.2010.03.048

Type

Journal article

Journal

Virology

Publication Date

07/2010

Volume

402

Pages

223 - 227

Addresses

Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

Keywords

Humans, HIV-1, HIV Infections, Substance Abuse, Intravenous, RNA, Viral, Cluster Analysis, Risk Factors, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA, Risk-Taking, Sequence Homology, Genotype, Geography, Blood Donors, Asia, gag Gene Products, Human Immunodeficiency Virus, Molecular Epidemiology