HIV-1 CRF07_BC and CRF08_BC are closely related circulating recombinant forms (CRFs) with serious public health consequences in China. The temporal and spatial dynamics of these CRFs were determined by estimating their times of divergence, using phylogenetic and Bayesian coalescent methods. Studies of the timelines of CRF07_BC and CRF08_BC trace the expansion of these strains back their origins to Yunnan province. The present study highlights the relevance of incorporating evolutionary and molecular epidemiological analyses into an in-depth understanding of the genesis of HIV epidemic, providing information for determining regional and global public health policies, including future vaccine strategies.

Original publication

DOI

10.1016/j.vaccine.2009.07.101

Type

Journal article

Journal

Vaccine

Publication Date

05/2010

Volume

28 Suppl 2

Pages

B39 - B44

Addresses

Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. takebe@nih.go.jp

Keywords

Humans, HIV-1, HIV Infections, RNA, Viral, Bayes Theorem, Sequence Analysis, DNA, Disease Outbreaks, Evolution, Molecular, Phylogeny, China, Genetic Variation, Molecular Epidemiology