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In this article we review the evidence for and against recombination in human mtDNA. If recombination occurs, there needs to be a route by which genetic material can incorporate itself into the mitochondrial genome, and hence between mitochondrial lineages. We review the evidence for possible routes and then review the current state of the population genetic evidence for recombination. We conclude that there is no firmly established route by which recombination can occur, and that while some of the population genetic evidence is suggestive of recombination, it is far from conclusive.

Original publication

DOI

10.1007/s002390010232

Type

Journal article

Journal

Journal of molecular evolution

Publication Date

10/2001

Volume

53

Pages

430 - 435

Addresses

Centre for the Study of Evolution & School of Biological Sciences, University of Sussex, Brighton, BNI 9QG, United Kingdom. a-c.eyre-walker@sussex.ac.uk

Keywords

Cell Nucleus, Humans, DNA, Mitochondrial, Genetics, Population, Evolution, Molecular, Phylogeny, Recombination, Genetic, Linkage Disequilibrium, Pseudogenes, Models, Genetic, Paternity, Female, Male