Insulin-like growth factor-1 (IGF-I) is important in normal brain development but in the adult brain, IGF-I overexpression may be a risk factor for tumor development.We examined the association between circulating concentrations of IGF-I and IGFBP-3 in relation to risk of gliomas (74 low-grade, 206 high-grade gliomas), meningiomas (n = 174) and acoustic neuromas (n = 49) by using a case-control design nested in the European Prospective Investigation into Cancer and Nutrition. IGF-I and IGFBP-3 were measured by ELISAs.Conditional logistic regression was used to compute ORs and corresponding 95% CIs.The risk of low-grade gliomas was elevated with increased IGF-I (OR = 3.60, 95% CI: 1.11-11.7; top vs. bottom quartile) and decreased with elevated IGFBP-3 concentrations (OR = 0.28, 95% CI: 0.09-0.84) after mutual adjustment of these two factors; these results became nonsignificant after exclusion of the first year of follow-up. No association was observed for high-grade gliomas or meningiomas. Both high IGF-I and IGFBP-3 concentrations were associated with risk of acoustic neuromas (IGF-I: OR = 6.63, 95% CI: 2.27-19.4, top vs. bottom tertile; IGFBP-3: OR = 7.07, 95% CI: 2.32-21.6), even after excluding the first year of follow-up.High concentrations of IGF-I might be positively associated with risk of low-grade gliomas and acoustic neuromas, although we cannot exclude reverse causation, in particular for low-grade gliomas.Factors of the IGF axis might be involved in the etiology of some types of brain tumors.

Original publication

DOI

10.1158/1055-9965.epi-11-0179

Type

Journal article

Journal

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Publication Date

10/2011

Volume

20

Pages

2174 - 2182

Addresses

Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany. sabine.rohrmann@ifspm.uzh.ch

Keywords

Humans, Glioma, Neuroma, Acoustic, Brain Neoplasms, Meningeal Neoplasms, Insulin-Like Growth Factor I, Insulin-Like Growth Factor Binding Protein 3, Enzyme-Linked Immunosorbent Assay, Prognosis, Case-Control Studies, Cohort Studies, Follow-Up Studies, Prospective Studies, Nutritional Status, Middle Aged, Female, Male, Biomarkers, Tumor