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BackgroundBipolar affective disorder (BPAD) and schizophrenia (SCZ) are common conditions. Their causes are unknown, but they include a substantial genetic component. Previously, we described significant linkage of BPAD to a chromosome 4p locus within a large pedigree (F22). Others subsequently have found evidence for linkage of BPAD and SCZ to this region.MethodsWe constructed high-resolution haplotypes for four linked families, calculated logarithm of the odds (LOD) scores, and developed a novel method to assess the extent of allele sharing within genes between the families.ResultsWe describe an increase in the F22 LOD score for this region. Definition and comparison of the linked haplotypes allowed us to prioritize two subregions of 3.8 and 4.4 Mb. Analysis of the extent of allele sharing within these subregions identified 200 kb that shows increased allele sharing between families.ConclusionsLinkage of BPAD to chromosome 4p has been strengthened. Haplotype analysis in the additional linked families refined the 20-Mb linkage region. Development of a novel allele-sharing method allowed us to bridge the gap between conventional linkage and association studies. Description of a 200-kb region of increased allele sharing prioritizes this region, which contains two functional candidate genes for BPAD, SLC2A9, and WDR1, for subsequent studies.

Original publication

DOI

10.1016/j.biopsych.2006.06.029

Type

Journal article

Journal

Biological psychiatry

Publication Date

03/2007

Volume

61

Pages

797 - 805

Addresses

Medical Genetics Section, School of Clinical and Molecular Medicine, Molecular Medicine Centre, University of Edinburgh, Scotland, United Kingdom.

Keywords

Chromosomes, Human, Pair 4, Humans, Population Surveillance, Pedigree, Bipolar Disorder, Haplotypes, Lod Score, Polymorphism, Single Nucleotide, Alleles, Models, Genetic, Female, Male, Genetic Linkage