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Respiratory syncytial virus (RSV) bronchiolitis is characterized by intense inflammation of the airways, and high levels of proinflammatory cytokines and chemokines can be found in respiratory secretions of affected infants. Important among these chemokines are RANTES (regulated on activation, normal T cell-expressed and -secreted) and macrophage inflammatory-protein alpha, MIP-1alpha, both of which show correlation with severe RSV bronchiolitis. It is not clear whether high levels of these chemokines are important in disease pathogenesis, and this study addresses this question by studying genetic variants of their major receptor, CC chemokine receptor 5. Results from both a case-control and family-based genetic-association analysis show that the -2459G and -2554T variants are associated with severe RSV bronchiolitis (P=.01). It is proposed that these CCR5 variants influence the inflammatory response, and these data provide further evidence of the important role that host genetic variability plays in the determination of disease severity in RSV bronchiolitis.

Original publication

DOI

10.1086/377587

Type

Journal article

Journal

The journal of infectious diseases

Publication Date

09/09/2003

Volume

188

Pages

904 - 907

Addresses

University Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford, UK. jhull@molbiol.ox.ac.uk

Keywords

Humans, Respiratory Syncytial Virus, Human, Bronchiolitis, Viral, Respiratory Syncytial Virus Infections, Genetic Predisposition to Disease, Receptors, CCR5, Severity of Illness Index, Case-Control Studies, Infant, Infant, Newborn, Genetic Variation