Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin secretory capacity in the setting of insulin resistance. We conducted meta-analyses of genome-wide association results for fasting proinsulin from 16 European-ancestry studies in 45,861 individuals. We found 36 independent signals at 30 loci (p value
Journal article
Am J Hum Genet
18/01/2023
GWAS, colocalization, conditional, eQTL, enhancer, fine-mapping, meta-analysis, proinsulin, signal, type 2 diabetes