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AbstractBrain ageis a widely used index for quantifying individuals’ brain health as deviation from a normative brain aging trajectory. Higher than expectedbrain ageis thought partially to reflect above-average rate of brain aging. We explicitly tested this assumption in two large datasets and found no association between cross-sectionalbrain ageand steeper brain decline measured longitudinally. Rather,brain agein adulthood was associated with early-life influences indexed by birth weight and polygenic scores. The results call for nuanced interpretations of cross-sectional indices of the aging brain and question their validity as markers of ongoing within-person changes of the aging brain. Longitudinal imaging data should be preferred whenever the goal is to understand individual change trajectories of brain and cognition in aging.

Original publication

DOI

10.1101/2021.02.08.428915

Type

Journal article

Publication Date

08/02/2021