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While there is strong epidemiological evidence that circulating insulin-like growth factor-I (IGF-I) is associated with a higher risk of several cancers, little is known about its association with non-cancer outcomes. We investigated associations of circulating IGF-I with risk of 25 common conditions, other than cancer, in a large British cohort. Study participants were 318,749 middle-aged adults enrolled in the UK Biobank Study. Serum IGF-I concentration was measured in samples collected at baseline (2006-2010), and re-measured in 12,334 participants after an average of 4.3 years. We followed-up participants over an average of 11.5 years by linking to hospital admissions and mortality registries. Multivariable-adjusted Cox regressions estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between circulating IGF-I and 25 common conditions, using the repeated IGF-I measurements to correct for regression dilution bias. After correction for multiple testing (P 

Original publication

DOI

10.1007/s10654-021-00811-y

Type

Journal article

Journal

European journal of epidemiology

Publication Date

01/2022

Volume

37

Pages

25 - 34

Addresses

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford, OX3 7LF, UK. Keren.Papier@ndph.ox.ac.uk.

Keywords

Humans, Insulin-Like Growth Factor I, Risk Factors, Prospective Studies, Adult, Middle Aged, Biological Specimen Banks, United Kingdom, Noncommunicable Diseases, Iron Deficiencies