A role for specific human leukocyte antigen (HLA) variants in the etiology of childhood acute lymphoblastic leukemia (ALL) has been extensively studied over the last 30 years, but no unambiguous association has been identified. To comprehensively study the relationship between genetic variation within the 4.5 Mb major histocompatibility complex genomic region and precursor B-cell (BCP) ALL risk, we analyzed 1075 observed and 8176 imputed single nucleotide polymorphisms and their related haplotypes in 824 BCP-ALL cases and 4737 controls. Using these genotypes we also imputed both common and rare alleles at class I (HLA-A, HLA-B, and HLA-C) and class II (HLA-DRB1, HLA-DQA1, and HLA-DQB1) HLA loci. Overall, we found no statistically significant association between variants and BCP-ALL risk. We conclude that major histocompatibility complex-defined variation in immune-mediated response is unlikely to be a major risk factor for BCP-ALL.

Original publication

DOI

10.1182/blood-2010-08-301598

Type

Journal article

Journal

Blood

Publication Date

02/2011

Volume

117

Pages

1633 - 1640

Addresses

Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom.

Keywords

Humans, Genetic Predisposition to Disease, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Case-Control Studies, Genotype, Haplotypes, Polymorphism, Single Nucleotide, Alleles, Child, Child, Preschool, Female, Male, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Genome-Wide Association Study