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The fixation of advantageous mutations by natural selection has a profound impact on patterns of linked neutral variation. While it has long been appreciated that such selective sweeps influence the frequency spectrum of nearby polymorphism, it has only recently become clear that they also have dramatic effects on local linkage disequilibrium. By extending previous results on the relationship between genealogical structure and linkage disequilibrium, I obtain simple expressions for the influence of a selective sweep on patterns of allelic association. I show that sweeps can increase, decrease, or even eliminate linkage disequilibrium (LD) entirely depending on the relative position of the selected and neutral loci. I also show the importance of the age of the neutral mutations in predicting their degree of association and describe the consequences of such results for the interpretation of empirical data. In particular, I demonstrate that while selective sweeps can eliminate LD, they generate patterns of genetic variation very different from those expected from recombination hotspots.

Original publication

DOI

10.1534/genetics.106.062828

Type

Journal article

Journal

Genetics

Publication Date

03/2007

Volume

175

Pages

1395 - 1406

Addresses

Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom. mcvean@stats.ox.ac.uk

Keywords

Linkage Disequilibrium, Mutation, Alleles, Models, Genetic, Computer Simulation, Genetic Variation, Selection, Genetic