Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The completion of the International HapMap Project marks the start of a new phase in human genetics. The aim of the project was to provide a resource that facilitates the design of efficient genome-wide association studies, through characterising patterns of genetic variation and linkage disequilibrium in a sample of 270 individuals across four geographical populations. In total, over one million SNPs have been typed across these genomes, providing an unprecedented view of human genetic diversity. In this review we focus on what the HapMap Project has taught us about the structure of human genetic variation and the fundamental molecular and evolutionary processes that shape it.

Original publication

DOI

10.1371/journal.pgen.0010054

Type

Journal article

Journal

Plos genetics

Publication Date

10/2005

Volume

1

Addresses

Department of Statistics, University of Oxford, Oxford, United Kingdom. mcvean@stats.ox.ac.uk

Keywords

Humans, Chromosome Mapping, Genetics, Population, Evolution, Molecular, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Alleles, Genome, Human, Genetic Variation