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In mammals, most new mutations occur in males. But a study of the evolution of a human X to Y chromosomal translocation has revealed a sex bias much lower than previous estimates. Patterns of substitution suggest that differential methylation between male and female germ lines is a key determinant of the mutation rate.

Original publication

DOI

10.1016/s0960-9822(00)00787-9

Type

Journal article

Journal

Current biology : cb

Publication Date

11/2000

Volume

10

Pages

R834 - R835

Addresses

Institute of Cell, Animal and Population Biology, King's Buildings, University of Edinburgh, UK. g.mcvean@ed.ac.uk

Keywords

X Chromosome, Y Chromosome, Animals, Humans, Translocation, Genetic, Evolution, Molecular, DNA Methylation, CpG Islands, Sexual Maturation, Female, Male