In mammals, most new mutations occur in males. But a study of the evolution of a human X to Y chromosomal translocation has revealed a sex bias much lower than previous estimates. Patterns of substitution suggest that differential methylation between male and female germ lines is a key determinant of the mutation rate.

Type

Journal article

Journal

Curr Biol

Publication Date

16/11/2000

Volume

10

Pages

R834 - R835

Keywords

Animals, CpG Islands, DNA Methylation, Evolution, Molecular, Female, Humans, Male, Sexual Maturation, Translocation, Genetic, X Chromosome, Y Chromosome