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Public health emergencies, such as an Ebola disease outbreak, provide a complex and challenging environment for the evaluation of candidate vaccines. Here, we outline the need for flexible and responsive vaccine trial designs to be used in public health emergencies, and we summarize recommendations for their use in this setting.

Original publication

DOI

10.1126/scitranslmed.aat0360

Type

Journal article

Journal

Science translational medicine

Publication Date

07/2019

Volume

11

Addresses

Department of Biostatistics, University of Florida, Gainesville, FL, USA. nataliedean@ufl.edu ilongini@ufl.edu.