Adverse effects of drugs on the development of ischaemic heart disease
Landray MJ.
Ischaemic heart disease is so common that even a small effect from widely used drugs would be important. Drugs such as thiazide diuretics, β-adrenoceptor agonists and antagonists, and folate antagonists can influence lipids, glucose tolerance, or homocysteine metabolism, but there is little overall evidence of deleterious effects. Cocaine and tobacco are much more likely to be responsible for ischaemic heart disease than any commonly used pharmaceutical agent.