Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Accept all cookies Reject all non-essential cookies Find out more

Design of vaccine efficacy trials during public health emergencies.

Dean NE., Gsell P-S., Brookmeyer R., De Gruttola V., Donnelly CA., Halloran ME., Jasseh M., Nason M., Riveros X., Watson CH., Henao-Restrepo AM., Longini IM.

Public health emergencies, such as an Ebola disease outbreak, provide a complex and challenging environment for the evaluation of candidate vaccines. Here, we outline the need for flexible and responsive vaccine trial designs to be used in public health emergencies, and we summarize recommendations for their use in this setting.

More information Original publication

DOI

10.1126/scitranslmed.aat0360

Type

Journal article

Publication Date

2019-07-01T00:00:00+00:00

Volume

11

Addresses

D, e, p, a, r, t, m, e, n, t, , o, f, , B, i, o, s, t, a, t, i, s, t, i, c, s, ,, , U, n, i, v, e, r, s, i, t, y, , o, f, , F, l, o, r, i, d, a, ,, , G, a, i, n, e, s, v, i, l, l, e, ,, , F, L, ,, , U, S, A, ., , n, a, t, a, l, i, e, d, e, a, n, @, u, f, l, ., e, d, u, , i, l, o, n, g, i, n, i, @, u, f, l, ., e, d, u, .

Keywords

Humans, Emergencies, Vaccines, Endpoint Determination, Public Health, Clinical Trials as Topic, Statistics as Topic