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The CHILDS Trust Medical Research Foundation (CTMRF), is a not for profit paediatric teaching hospital in Chennai, India. The Foundation are conducting surveillance of AMR in bacterial pathogens causing paediatric infectious diseases. They are addressing these challenges by joining AMR surveillance Networks (GRAM, WHO-GLASS) and sharing their data, while also submitting grants to support AMR research in India (GRAM, Indian Council for Medical Research), with enhanced collaboration with other stake holders. Anand Manoharan is the Director of Research at CTMRF.

Help us understand...about your collaboration with GRAM

We are sharing the data we collect in our center on antimicrobial susceptibility testing. Surveillance of AMR in paediatric population is important and helps in better treatment and management of paediatric infectious diseases. Surveillance tools, elucidating underlying mechanisms of AMR, educating and training new staff to understand the growing problem of AMR all interest me. I think the global estimate of AMR is important as AMR is a global phenomenon and thus far reliable estimates of Global AMR are missing.

Help us understand...the context of AMR

Drug resistant infections in India increase days of hospitalization, due to unnecessary use of antibiotic combinations, which also increase health care costs. Antibiotics are available locally in both hospital based pharmacies and local pharmacies. In India access is not a major constraint, overuse of antibiotics is the major concern. I worry about overuse of antibiotics, over the counter dispensing, lack of proper laboratory methods for diagnosing AMR, data sharing and lack of public-private partnership. Strengthening laboratory capacity for AMR detection, Surveillance, data-sharing, education and training are all methods to improve our understanding and ability to combat AMR.

Due to COVID-19 our laboratory is currently seeing a very low patient turnout and therefore less samples for routine clinical laboratory investigations. This will increase use of antibiotics especially in high risk individuals with COVID-19 and will likely lead to higher prescription rates in children with respiratory infections. 

Help us understand...your perspective on the global picture and the future

In my opinion the global AMR need to look to increase the interconnectedness of data, enhanced public health communication to promote rational use of antibiotics and strengthen laboratory infrastructure in low and middle income countries. I think over the next five to ten years we will see newer antibiotics with novel mechanisms of action together with better surveillance tools and reliable country, regional and global AMR estimates.


Front standing Left to Right- Dr.Sara Chandy, Dr.Anand Manoharan, Dr.Senthilnathan, Mr.Venkatraman

Back standing Left to Right- Ms.Akshya, Ms.Rama Devi, Ms.Surekha, Mr.Gurudoss and Mr.Robinson.