Professor Cornelia Marja van Duijn
Cornelia Marja van Duijn
Professor of Epidemiology, Nuffield Department of Population Health
Cornelia M van Duijn is Professor of Epidemiology at Nuffield Department of Population Health (NDPH) and Fellow of St Cross College, Oxford. Her group is based at the Oxford Big Data Institute where she integrates large-scale (epi)genetic, transcriptomic, proteomic, metabolomic and microbiome data of epidemiological cohorts with that of brain imaging and cellular models. This involves novel approaches to analyse high-dimensional big data as well as the translation of classical epidemiological design and analysis strategies to functional research in cellular and organ-on-chip models.
Cornelia’s research focuses on brain and ocular diseases such as Alzheimer disease and glaucoma but her interest spans systemic vascular, endocrine and gastrointestinal pathology relevant for brain and ocular function. Her group is exploring new –omics frontiers of etiologic and translational genetic-epidemiologic research with mission to advance population health. This involves repurposing studies of life style and therapeutic interventions by enriching stored samples with genomics, proteomics and metabolomics as instruments to understand human gene-exposome interactions that determine brain and ocular health.
Her research portfolio further includes proteomic and metabolomics studies as key intermediate players linking the human genome and microbiome to brain and ocular health and as targets towards new avenues for disease prevention.
Impact of cumulative SBP and serious adverse events on efficacy of intensive blood pressure treatment: a randomized clinical trial.
Rueda-Ochoa OL. et al, (2019), Journal of hypertension, 37, 1058 - 1069
Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine.
Onderwater GLJ. et al, (2019), Neurology, 92, e1899 - e1911
Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects.
Mishra A. et al, (2019), Brain : a journal of neurology, 142, 1009 - 1023
The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk.
Belbin O. et al, (2019), Journal of Alzheimer's disease : JAD
Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population.
van der Plaat DA. et al, (2019), BMC pulmonary medicine, 19