Professor Cornelia Marja van Duijn
Cornelia Marja van Duijn
Professor of Epidemiology, Nuffield Department of Population Health
Cornelia M van Duijn is Professor of Epidemiology at Nuffield Department of Population Health (NDPH) and Fellow of St Cross College, Oxford. Her group is based at the Oxford Big Data Institute where she integrates large-scale (epi)genetic, transcriptomic, proteomic, metabolomic and microbiome data of epidemiological cohorts with that of brain imaging and cellular models. This involves novel approaches to analyse high-dimensional big data as well as the translation of classical epidemiological design and analysis strategies to functional research in cellular and organ-on-chip models.
Cornelia’s research focuses on brain and ocular diseases such as Alzheimer disease and glaucoma but her interest spans systemic vascular, endocrine and gastrointestinal pathology relevant for brain and ocular function. Her group is exploring new –omics frontiers of etiologic and translational genetic-epidemiologic research with mission to advance population health. This involves repurposing studies of life style and therapeutic interventions by enriching stored samples with genomics, proteomics and metabolomics as instruments to understand human gene-exposome interactions that determine brain and ocular health.
Her research portfolio further includes proteomic and metabolomics studies as key intermediate players linking the human genome and microbiome to brain and ocular health and as targets towards new avenues for disease prevention.
A genome-wide association study identifies genetic loci associated with specific lobar brain volumes
van der Lee SJ. et al, (2019), Communications Biology, 2
A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
Deelen J. et al, (2019), Nature Communications, 10
Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum
van der Laan T. et al, (2019), Scientific Reports, 9
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
Patsopoulos NA. et al, (2019), Science, 365
Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology.
Spracklen CN. et al, (2019), Am J Hum Genet, 105, 670 - 671