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We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there may be differences in progression and clinical appearance in early-onset AD related to the APOE genotype.

Original publication

DOI

10.1007/bf00900501

Type

Journal article

Journal

Journal of neurology

Publication Date

06/1996

Volume

243

Pages

465 - 468

Addresses

Department of Epidemiology & Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.

Keywords

Humans, Alzheimer Disease, Apolipoproteins, Prognosis, Alleles, Middle Aged, Female, Male