Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

To evaluate the association between lifestyle and dietary factors and serum concentrations of androgens in middle-aged healthy men.We conducted a cross-sectional analysis of the association of lifestyle factors with circulating concentrations of androstenedione (A-dione), 3-alpha-androstanediol glucuronide (A-diol-g), testosterone (T), SHBG (sex hormone-binding globulin), and free testosterone (FT) among 636 men in the European Prospective Investigation into Cancer and Nutrition.Compared with the youngest age group (40-49 years), the oldest (70-79 years) had a higher mean concentration of SHBG (by 44%) and lower mean concentrations of A-diol-g (by 29%) FT (19%). Men in the highest BMI group (> or =29.83 kg/m(2)) had a higher mean A-diol-g concentration (by 38%) and lower mean concentration of T (by 20%) SHBG (29%) compared with the lowest (<24.16 kg/m(2)). Current smokers had higher mean concentrations of T (by 13%), SHBG (14%), and A-dione (15%) compared with never smokers. Physical activity and dietary factors were not associated with androgen concentrations, although men in the highest fifth of alcohol intake had higher mean concentrations of A-dione (by 9%), FT (11%) compared with the lowest.Our results suggest that age, body weight, smoking, and alcohol intake are associated with circulating androgen concentrations in men.

Original publication

DOI

10.1007/s10552-009-9326-y

Type

Journal article

Journal

Cancer causes & control : CCC

Publication Date

08/2009

Volume

20

Pages

811 - 821

Addresses

Cancer Epidemiology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK. resuzuki@ncc.go.jp

Keywords

Humans, Neoplasms, Body Weight, Androstane-3,17-diol, Androstenedione, Testosterone, Sex Hormone-Binding Globulin, Androgens, Prospective Studies, Cross-Sectional Studies, Smoking, Life Style, Age Factors, Nutritional Status, Alcoholic Beverages, Middle Aged, Europe, Male, Multicenter Studies as Topic, Surveys and Questionnaires